Reid Hoffman, cofounder of Manas AI , has called on doctors to treat frontier AI models as a second opinion, arguing that the technology could reduce drug discovery timelines from a decade to a few years. The former LinkedIn executive, who also sits on the boards of PayPal and OpenAI , said the models ingest trillions of words and can provide a "superpower" that no human can match. Hoffman's remarks came after a study warned that large language models can give inaccurate medical advice to the public. He noted that the UK's National Health Service faces long waiting lists and a shortage of family doctors, and suggested a free medical assistant on every smartphone could help triage patients. The startup's focus remains on cancer drug discovery, but it plans to expand to other diseases. The company's mission is to shift drug discovery from a decade-long process to one that takes a few years. Hoffman said he personally uses frontier models as a second opinion for his own health and that his concierge doctors do the same. He also said that in 10 years every major disease will have target molecules that could at least make a serious difference. Hoffman told the WIRED Health audience that if a doctor does not use a frontier model as a second opinion, "you're making a mistake, both as a doctor and as a patient." He added that the models, though not specifically trained for medicine, have ingested "trillion-plus words of information." Hoffman emphasized that the FDA would need to run tests with biological models to fast-track promising drugs, a process he said is unlikely soon. While Manas AI still relies on human judgment to vet AI-generated targets, the company's approach could accelerate the availability of treatments for rare and chronic diseases that have historically been neglected. If the technology gains wider acceptance, it could reshape how medical research and clinical decision-making are conducted, offering a new tool for clinicians under pressure.